药物信息为AMOXICILLIN AND CLAVULANATE POTASSIUM Tablets, USP (American Health Packaging): DESCRIPTION

Amoxicillin and clavulanate potassium for oral suspension, and amoxicillin and clavulanate potassium tablets(chewable) is an oral antibacterial combination consisting of the semisynthetic antibiotic amoxicillin and the ß-lactamase inhibitor, clavulanate potassium (the potassium salt of clavulanic acid). Amoxicillin is an analog of ampicillin, derived from the basic penicillin nucleus, 6- aminopenicillanic acid. The amoxicillin molecular formula is C 16H19N3O5S•3H2O, and the molecular weight is 419.46. Chemically, amoxicillin is (2S,5R,6R)-6-[(R)-(-)-2-Amino-2-(p-hydroxyphenyl) acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate and may be represented structurally as:

Clavulanic acid is produced by the fermentation of Streptomyces clavuligerus. It is a ß-lactam structurally related to the penicillins and possesses the ability to inactivate a wide variety of ß-lactamases by blocking the active sites of these enzymes. Clavulanic acid is particularly active against the clinically important plasmid-mediated ß-lactamases frequently responsible for transferred drug resistance to penicillins and cephalosporins. The clavulanate potassium molecular formula is C8H8KNO5, and the molecular weight is 237.25. Chemically, clavulanate potassium is potassium (Z )-(2R,5R)-3-(2-hydroxyethylidene)-7-oxo-4- oxa-1-azabicyclo[3.2.0]-heptane-2-carboxylate and may be represented structurally as:

Each film coated tablet contains 500 mg amoxicillin as the trihydrate and 125 mg clavulanic acid as clavulanate potassium* or 875 mg amoxicillin as the trihydrate and 125 mg clavulanic acid as clavulanate potassium*. In addition, each film coated tablet containing 500 mg amoxicillin as the trihydrate and 125 mg clavulanic acid as clavulanate potassium* and 875 mg amoxicillin as the trihydrate and 125 mg clavulanic acid as clavulanate potassium* salt contains 0.63 mEq potassium.

*The potassium salt of clavulanic acid.Inactive Ingredients: colloidal silicon dioxide, eudragit E 100, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, sodium starch glycolate, talc and titanium dioxide.