药物信息为Cimetidine Hydrochloride Oral Solution (Hi-Tech Pharmacal Co., Inc.): DESCRIPTION

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  • Cimetidine is a histamine H2-receptor antagonist. Chemically it is N"-cyano-N-methyl-N'-[2-[[(5-methyl-1 H-imidazol-4-yl) methyl]thio]-ethyl], guanidine.

    The molecular formula for cimetidine hydrochloride is C10H16N6S?HCI and the molecular weight is 288.80. The structural formula of cimetidine hydrochloride is:

    Cimetidine contains an imidazole ring, and is chemically related to histamine.

    Cimetidine has a bitter taste and characteristic odor.

  • Solubility Characteristics

  • Cimetidine hydrochloride is freely soluble in water, soluble in alcohol, very slightly soluble in chloroform and practically insoluble in ether.

    Each 5 mL (1 teaspoonful), for oral administration, contains cimetidine hydrochloride equivalent to cimetidine, 300 mg; alcohol, 2.8%. In addition, the oral solution contains the following inactive ingredients: FD&C Yellow No. 6, hydrochloric acid, methylparaben, natural orange flavor, polyoxyethylene, polyoxypropylene glycol, propylene glycol, propylparaben, purified water, saccharin sodium, sodium chloride, dibasic sodium phosphate anhydrous, and sorbitol. The pH range is 5.1 to 5.7.

  • Drug Information Provided by National Library of Medicine (NLM).
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