药物信息为CIMETIDINE HYDROCHLORIDE ORAL SOLUTION0506 (TEVA PHARMACEUTICALS USA): DESCRIPTION

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  • Cimetidine is a histamine H2-receptor antagonist. Chemically it is N"-cyano-N-methyl-N'-[2-[[(5-methyl-1H-imidazol-4-yl) methyl]thio]-ethyl]-guanidine. The structural formula is:

    C10H16N6S•HCl M.W. 288.80

    Cimetidine contains an imidazole ring, and is chemically related to histamine.

    (The liquid dosage form contains cimetidine as the hydrochloride.)

    Cimetidine hydrochloride has a bitter taste and characteristic odor.

  • Solubility Characteristics

  • Cimetidine hydrochloride is freely soluble in water, soluble in alcohol, very slightly soluble in chloroform and practically insoluble in ether.

    Each 5 mL (one teaspoonful), for oral administration contains, cimetidine hydrochloride equivalent to 300 mg of cimetidine; alcohol, 2.8%. Inactive ingredients consist of FD&C Yellow No. 6, artificial peach mint flavor, hydrochloric acid, methylparaben, poloxamer 407, propylene glycol, propylparaben, purified water, saccharin sodium, sodium chloride, dibasic sodium phosphate heptahydrate and sorbitol solution.

  • Drug Information Provided by National Library of Medicine (NLM).
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