药物信息为CLARITHROMYCIN (KAISER FOUNDATION HOSPITALS): CONTRAINDICATIONS
- CLINICAL PHARMACOLOGY
- INDICATIONS AND USAGE
- Information For Patients
- Drug Interactions
- Carcinogenesis, Mutagenesis, Impairment of Fertility
- Nursing Mothers
- Geriatric Use
- ADVERSE REACTIONS
- DOSAGE AND ADMINISTRATION
- HOW SUPPLIED
- CLINICAL STUDIES
- ANIMAL PHARMACOLOGY AND TOXICOLOGY
- 外部链接相关的CLARITHROMYCIN (KAISER FOUNDATION HOSPITALS)
Clarithromycin is contraindicated in patients with a known hypersensitivity to clarithromycin,erythromycin, or any of the macrolide antibiotics.
Concomitant administration of clarithromycin and any of the following drugs is contraindicated:cisapride, pimozide, astemizole, terfenadine and ergotamine or dihydroergotamine (See DrugInteractions). There have been post-marketing reports of drug interactions when clarithromycin and/orerythromycin are coadministered with cisapride, pimozide, astemizole, or terfenadine resulting incardiac arrhythmias (QT prolongation, ventricular tachycardia, ventricular fibrillation, and torsades depointes) most likely due to inhibition of metabolism of these drugs by erythromycin and clarithromycin.Fatalities have been reported.
For information about contraindications of other drugs indicated in combination with clarithromycin,refer to the CONTRAINDICATIONS section of their package inserts.
- Drug Information Provided by National Library of Medicine (NLM).