药物信息为Clindamycin Phosphate and Benzoyl Peroxide (Mylan Pharmaceuticals Inc.): CLINICAL PHARMACOLOGY

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  • An in vitro percutaneous penetration study comparing ClindamycinPhosphate and Benzoyl Peroxide Gel, 1%/5% and topical 1% clindamycin gel alone, demonstrated there was no statistical difference in penetration between the two drugs. Mean systemic bioavailability of topical clindamycin in ClindamycinPhosphate and Benzoyl Peroxide Gel, 1%/5% is suggested to be less than 1%.

    Benzoyl peroxide has been shown to be absorbed by the skin where it is converted to benzoic acid. Less than 2% of the dose enters systemic circulation as benzoic acid. It is suggested that the lipophilic nature of benzoyl peroxide acts to concentrate the compound into the lipid-rich sebaceous follicle.

  • Microbiology

  • The clindamycin and benzoyl peroxide components individually have been shown to have in vitro activity against Propionibacterium acnes an organism which has been associated with acne vulgaris; however, the clinical significance of this activity against P. acnes was not examined in clinical trials with this product.

  • Drug Information Provided by National Library of Medicine (NLM).
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