药物信息为Codeprex™ Pennkinetic (codeine polistirex and chlorpheniramine polistirex) Extended-Release Suspension CIII (Celltech Pharmaceuticals, Inc.): DESCRIPTION

Codeprex Extended-Release Suspension is a pink to purple-pink colored, cherry-cream flavored suspension. Each teaspoonful (5 mL) of Codeprex Extended-Release Suspension contains codeine polistirex equivalent to 20 mg of codeine and chlorpheniramine polistirex equivalent to 4 mg of chlorpheniramine maleate and excipients. These excipients include: Citric acid (anhydrous), D&C Red No. 33, edetate disodium, ethylcellulose, flavor, glycerin, methylparaben, microcrystalline cellulose, carboxymethylcellulose sodium, polyethylene glycol 3350, polysorbate 80, propylparaben, propylene glycol, purified water, sodium hydroxide, sodium polystyrene sulfonate, sucrose, vegetable oil, and xanthan gum. Codeine is an opiate antitussive. Chlorpheniramine is an antihistamine. Codeprex is for oral use only.

Chemically, codeine is (5α,6α)-7,8-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol. Its empirical formula is C₁₈H₂₁NO₃, and its molecular weight is 299.36. Codeine polistirex is the sulfonated styrene-divinylbenzene copolymer complex with codeine. Its structural formula is:

Chemically, chlorpheniramine is γ-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine. Its empirical formula is C₁₆H₁₉ClN₂, and its molecular weight is 274.80 (free base). Chlorpheniramine polistirex is the sulfonated styrene-divinylbenzene copolymer complex with chlorpheniramine. Its structural formula is: