药物信息为Diltiazem Hydrochloride Extended Release Tablets Issued: October 2005 Rx Only Once-a-day dosage (Watson Laboratories Inc.): DESCRIPTION

Diltiazem hydrochloride is a calcium ion cellular influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem hydrochloride is 1,5-benzothiazepin-4(5H) one,3-(acetyloxy)-5-[2-(dimethylamino) ethyl]-2, 3-dihydro-2-(4-methoxyphenyl)-, monohydrochloride, (+)-cis-.

The structural formula is:

Diltiazem hydrochloride is a white to off-white crystalline powder with a bitter taste. It is soluble in water, methanol and chloroform. It has a molecular weight of 450.99. Diltiazem Hydrochloride Extended Release Tablets, for oral administration, are formulated as a once-a-day extended release tablet containing either120 mg, 180 mg, 240 mg, 300 mg, 360 mg or 420 mg of diltiazem hydrochloride.

Also contains: Monosodium Citrate Anhydrous Powder; Polyethylene Glycol, NF (PEG-6000); Povidone, USP; Magnesium Stearate, NF; Dehydrated Alcohol, USP; Lactose Monohydrate, NF; Acetyltributyl Citrate, NF; Sodium Bicarbonate, USP; Multipor^® Coating Polymer; Titanium Dioxide, USP; Acetone, NF; Ethylcellulose, NF; Hypromellose, USP; Purified Water, USP; Talc, USP; Isopropyl Alcohol, USP; n-Butyl Alcohol, NF; Propylene Glycol, USP; Opacode Black Ink.