药物信息为Dorzolamide Hydrochloride Ophthalmic Solution Sterile Ophthalmic Solution 2% (Sandoz Inc.): DESCRIPTION

Dorzolamide Hydrochloride Ophthalmic Solution is a carbonic anhydrase inhibitor formulated for topical ophthalmic use.

Dorzolamide hydrochloride is described chemically as: (4S-trans)-4-(ethylamino)-5,6-dihydro-6-methyl-4Hthieno[ 2,3-b]thiopyran-2-sulfonamide 7,7-dioxide monohydrochloride. Dorzolamide hydrochloride is optically active. The specific rotation is

Its empirical formula is C₁₀H₁₆N₂O₄S₃•HCl and its structural formula is:

Dorzolamide hydrochloride has a molecular weight of 360.9 and a melting point of about 264°C. It is a white to offwhite, crystalline powder, which is soluble in water and slightly soluble in methanol and ethanol.

Dorzolamide Hydrochloride Ophthalmic Solution is supplied as a sterile, isotonic, buffered, slightly viscous, aqueous solution of dorzolamide hydrochloride. The pH of the solution is approximately 5.6, and the osmolarity is 260-330 mOsM. Each mL of Dorzolamide Hydrochloride Ophthalmic Solution 2% contains 20 mg dorzolamide (22.3 mg of dorzolamide hydrochloride). Inactive ingredients are hydroxyethyl cellulose, mannitol, purified water, sodium citrate dihydrate. Sodium Hydroxide may be used to adjust pH. Benzalkonium chloride 0.0075% is added as a preservative.