药物信息为Enalapril Maleate Tablets, USP (Sandoz Inc.): Heart Failure

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  • Enalapril Maleate Tablets is indicated for the treatment of symptomatic heart failure, usually in combination with diuretics and digitalis. In the placebocontrolled studies that demonstrated improved survival, patients were titrated as tolerated up to 40 mg, administered in two divided doses. The recommended initial dose is 2.5 mg. The recommended dosing range is 2.5 to 20 mg given twice a day. Doses should be titrated upward, as tolerated, over a period of a few days or weeks. The maximum daily dose administered in clinical trials was 40 mg in divided doses.

    After the initial dose of Enalapril Maleate Tablets, the patient should be observed

    under medical supervision for at least two hours and until blood pressure has stabilized for at least an additional hour. (See WARNINGSand PRECAUTIONS,Drug Interactions.) If possible, the dose of any concomitant diuretic should be reduced which may diminish the likelihood of hypotension. The appearance of hypotension after the initial dose of enalapril maleate tablets does not preclude subsequent careful dose titration with the drug, following effective management of the hypotension.

  • Drug Information Provided by National Library of Medicine (NLM).
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