药物信息为ENBREL (etanercept) For Subcutaneous Injection (Immunex Corp): OVERDOSAGE

The maximum tolerated dose of ENBREL^® has not been established in humans. Toxicology studies have been performed in monkeys at doses up to 30 times the human dose with no evidence of dose-limiting toxicities. No dose-limiting toxicities have been observed during clinical trials of ENBREL^®. Single IV doses up to 60 mg/m² have been administered to healthy volunteers in an endotoxemia study without evidence of dose-limiting toxicities.