药物信息为EPOPROSTENOL (GeneraMedix Inc ): CONTRAINDICATIONS

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  • A large study evaluating the effect of epoprostenol on survival in NYHA Class III and IV patients with congestive heart failure due to severe left ventricular systolic dysfunction was terminated after an interim analysis of 471 patients revealed a higher mortality in patients receiving epoprostenol plus conventional therapy than in those receiving conventional therapy alone. The chronic use of epoprostenol in patients with congestive heart failure due to severe left ventricular systolic dysfunction is therefore contraindicated.

    Some patients with pulmonary hypertension have developed pulmonary edema during dose initiation, which may be associated with pulmonary veno-occlusive disease. Epoprostenol should not be used chronically in patients who develop pulmonary edema during dose initiation.

    Epoprostenol is also contraindicated in patients with known hypersensitivity to the drug or to structurally related compounds.

  • Drug Information Provided by National Library of Medicine (NLM).
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