药物信息为Isocaine 3% injection (Mepivacaine Hydrochloride Injection, USP 3%) Isocaine 2%with Levonordefrin 1:20,000 injection (Mepivacaine Hydrochloride and Levonordefrin Injection, USP) (Septodont Inc): DESCRIPTION

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  • ISOCAINE (Mepivacaine Hydrochloride), a tertiary amine used as a local anesthetic, is 1-methyl-2', 6' - pipecoloxylidide monohydrochloride with the following structural formula:

    It is a white, crystalline, odorless powder soluble in water, but very resistant to both acid and alkaline hydrolysis.

    Levonordefrin, a sympathomimetic amine used as a vasoconstrictor in local anesthetic solution, is (-)-a-(1-Aminoethyl)-3, 4-dihydroxybenzyl alcohol with the following structural formula:

    It is a white or buff-colored crystalline solid, freely soluble in aqueous solutions of mineral acids, but practically insoluble in water.

    DENTAL CARTRIDGES MAY NOT BE AUTOCLAVED.

    ISOCAINE 3% Injection and ISOCAINE 2% with Levonordefrin 1:20,000 Injection are sterile solutions for injection.

    COMPOSITIONCARTRIDGE
    Each mL contains:2%3%
    Mepivacaine Hydrochloride20 mg30 mg
    Levonordefrin (as the base)0.05 mg-
    Sodium Chloride4 mg3 mg
    Sodium Bisulfite1 mg-
    Water For Injection, qs. ad.1 mL1 mL
    The pH of the 2% cartridge solution is adjusted between 3.3 and 5.5 with NaOH or HCI.
    The pH of the 3% cartridge solution is adjusted between 4.5 and 6.8 with NaOH or HCI.
  • Drug Information Provided by National Library of Medicine (NLM).
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