药物信息为KEPPRA XR (UCB, Inc.): 2 DOSAGE AND ADMINISTRATION

Treatment should be initiated with a dose of 1000 mg once daily. The daily dosage may be adjusted in increments of 1000 mg every 2 weeks to a maximum recommended daily dose of 3000 mg.
2.1 Adult Patients With Impaired Renal Function

KEPPRA XR dosing must be individualized according to the patient's renal function status. Recommended doses and adjustment for dose for adults are shown in Table 1. To use this dosing table, an estimate of the patient's creatinine clearance (CLcr) in mL/min is needed. CLcr in mL/min may be estimated from serum creatinine (mg/dL) determination using the following formula:

[140-age (years)] x weight (kg) CLcr = ---------------------------------------------- x ¹ 0.85 72 x serum creatinine (mg/dL)^1. For female patients

Then CLcr is adjusted for body surface area (BSA) as follows:

CLcr (mL/min) CLcr (mL/min/1.73m²) = ----------------------------- x 1.73 BSA subject (m²)

Table 1: Dosing Adjustment Regimen For Adult Patients With Impaired Renal Function
Group	CreatinineClearance(mL/min/1.73m²)	Dosage(mg)	Frequency
Normal	> 80	1000 to 3000	Every 24 h
Mild	50 – 80	1000 to 2000	Every 24 h
Moderate	30 – 50	500 to 1500	Every 24 h
Severe	< 30	500 to 1000	Every 24 h

Drug Information Provided by National Library of Medicine (NLM).

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药物信息为KEPPRA XR (UCB, Inc.): 2 DOSAGE AND ADMINISTRATION

2.1 Adult Patients With Impaired Renal Function