药物信息为Levetiracetam Tablets (Caremark L.L.C.): DESCRIPTION

Levetiracetam is an antiepileptic drug available as 250 mg (blue), 500 mg (yellow), 750 mg (light beige) and 1000 mg (white) tablets for oral administration.

The chemical name of levetiracetam, a single enantiomer, is (­)­(S)­a­ethyl­2­oxo­1-pyrrolidine acetamide, its molecular formula is C₈H₁₄N₂O₂ and its molecular weight is 170.21. Levetiracetam is chemically unrelated to existing antiepileptic drugs (AEDs). It has the following structural formula:

Levetiracetam is a white to off-white crystalline powder with a faint odor and a bitter taste. It is very soluble in water (104 g/100 mL). It is freely soluble in chloroform (65.3 g/100 mL) and in methanol (53.6 g/100 mL), soluble in ethanol (16.5 g/100 mL), sparingly soluble in acetonitrile (5.7 g/100 mL) and practically insoluble in n­hexane. (Solubility limits are expressed as g/100 mL solvent.)

Levetiracetam Tablets contain the labeled amount of levetiracetam. Inactive ingredients: colloidal silicon dioxide, hydroxypropyl cellulose, magnesium stearate, microcrystalline cellulose, and modified cellulose gum. In addition to the ingredients listed above, the 250 mg tablet contains Opadry II (Blue), the 500 mg tablet contains Opadry II (Yellow), the 750 mg tablet contains Opadry II (Flesh) and the 1000 mg tablet contains Opadry II (white). Opadry II (Blue) contains FD&C Blue #2, hypromellose, macrogol, polydextrose, titanium dioxide, and triacetin. Opadry II (Yellow) contains hypromellose, iron oxide yellow, macrogol, polydextrose, titanium dioxide, and triacetin. Opadry II (Flesh) contains hypromellose, iron oxide yellow, iron oxide red, macrogol, polydextrose, titanium dioxide, and triacetin. Opadry II (white) contains hypromellose, polyethylene glycol, polydextrose, titanium dioxide, and triacetin.