药物信息为MEVACOR (LOVASTATIN) TABLETS (Merck & Co., Inc.): DESCRIPTION

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  • MEVACOR

    Registered trademark of MERCK & CO., Inc.COPYRIGHT © 1987-2007 MERCK & CO., Inc.All rights reserved

    (Lovastatin) is a cholesterol lowering agent isolated from a strain of Aspergillus terreus. After oral ingestion, lovastatin, which is an inactive lactone, is hydrolyzed to the corresponding β‑hydroxyacid form. This is a principal metabolite and an inhibitor of 3‑hydroxy-3‑methylglutaryl-coenzyme A (HMG‑CoA) reductase. This enzyme catalyzes the conversion of HMG‑CoA to mevalonate, which is an early and rate limiting step in the biosynthesis of cholesterol.

    Lovastatin is [1S -[1α(R*),3α,7β,8β(2S*,4S*), 8aβ]]-1,2,3,7, 8,8a‑hexahydro-3,7‑dimethyl-8-[2‑(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2‑yl) ethyl]-1-naphthalenyl 2-methylbutanoate. The empirical formula of lovastatin is C24H36O5 and its molecular weight is 404.55. Its structural formula is:

    Lovastatin is a white, nonhygroscopic crystalline powder that is insoluble in water and sparingly soluble in ethanol, methanol, and acetonitrile.

    Tablets MEVACOR are supplied as 20 mg and 40 mg tablets for oral administration. In addition to the active ingredient lovastatin, each tablet contains the following inactive ingredients: cellulose, lactose, magnesium stearate, and starch. Butylated hydroxyanisole (BHA) is added as a preservative. Tablets MEVACOR 20 mg also contain FD&C Blue 2 aluminum lake. Tablets MEVACOR 40 mg also contain D&C Yellow 10 aluminum lake and FD&C Blue 2 aluminum lake.

  • Drug Information Provided by National Library of Medicine (NLM).
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