药物信息为NOVOCAIN PROCAINE HYDROCHLORIDE INJECTION, USP (Hospira, Inc.): DESCRIPTION

Procaine hydrochloride is benzoic acid, 4-amino-, 2-(diethylamino) ethyl ester, monohydrochloride, the ester of diethylaminoethanol and para-aminobenzoic acid, with the following structural formula:

It is a white crystalline, odorless powder that is freely soluble in water, but less soluble in alcohol and has a molecular weight of 272.78.

Composition of Available Solutions
Each mL contains	1% Ampul	1% Vial	2% Vial
[Acetone sodium bisulfite is added as an antioxidant in all products, and chlorobutanol is added as an antimicrobial preservative in the multiple-dose vials.]
Procaine hydrochloride	10 mg	10 mg	20 mg
Acetone sodium bisulfite	≤ 1 mg	≤ 2 mg	≤ 2 mg
Chlorobutanol	–	≤ 2.5 mg	≤ 2.5 mg

The solutions are made isotonic with sodium chloride and the pH is adjusted between 3 and 5.5 with sodium hydroxide and/or hydrochloric acid.

Procaine hydrochloride is related chemically and pharmacologically to the ester-type local anesthetics. It contains an ester linkage between the aromatic nucleus and the amino group.

NOVOCAIN is available as sterile solutions in concentrations of 1% and 2% for injection via local infiltration and peripheral nerve block.

Drug Information Provided by National Library of Medicine (NLM).

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