药物信息为ORAVIG (miconazole) buccal tablets (Par Pharmaceuticals Companies, Inc.): 11 DESCRIPTION

ORAVIG (miconazole) buccal tablets are applied topically to the gum once daily and release miconazole as the buccal tablet gradually dissolves [see Clinical Pharmacology (12.3)].

Miconazole is an imidazole antifungal agent and is described chemically as 1-[(2RS)-2-[(2,4-dichlorobenzyl) oxy]-2-(2,4-dichlorophenyl) ethyl]-1H-imidazole with an empirical formula of C₁₈H₁₄C_l4N₂O and a molecular weight of 416.13. The structural formula is shown in Figure 1.

Miconazole drug substance is a white to almost white powder.

ORAVIG contains 50 mg of miconazole base, USP and the following inactive ingredients: hypromellose, USP; milk protein concentrate; corn starch, NF; lactose monohydrate, NF; sodium lauryl sulfate, NF; magnesium stearate, NF; and talc, USP.