药物信息为SERTRALINE HCl (Caremark L.L.C.): DRUG ABUSE AND DEPENDENCE

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  • Controlled Substance Class

    Sertraline hydrochloride is not a controlled substance.

    Physical and Psychological Dependence

    In a placebo-controlled, double-blind, randomized study of the comparative abuse liability of sertraline, alprazolam, and d-amphetamine in humans, sertraline did not produce the positive subjective effects indicative of abuse potential, such as euphoria or drug liking, that were observed with the other two drugs. Premarketing clinical experience with sertraline did not reveal any tendency for a withdrawal syndrome or any drug-seeking behavior. In animal studies sertraline does not demonstrate stimulant or barbiturate-like (depressant) abuse potential. As with any CNS active drug, however, physicians should carefully evaluate patients for history of drug abuse and follow such patients closely, observing them for signs of sertraline misuse or abuse (e.g., development of tolerance, incrementation of dose, drug-seeking behavior).

  • Drug Information Provided by National Library of Medicine (NLM).
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