药物信息为Verapamil HydrochloridePM (Mylan Pharmaceuticals Inc.): DESCRIPTION

Verapamil hydrochloride is a calcium ion influx inhibitor (slow channel blocker or calcium ion antagonist). Verapamil hydrochloride extended-release capsules (PM) are available for oral administration as a 100 mg, 200 mg or 300 mg hard-shell gelatin capsule. Verapamil is administered as a racemic mixture of the R and S enantiomers.

The structural formula of verapamil hydrochloride is:

Chemical name: Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl) ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-,monohydrochloride,(±)-. Verapamil hydrochloride, USP is an almost white crystalline powder, practically free of odor, with a bitter taste. It is soluble in water, chloroform, and methanol. Verapamil hydrochloride is not structurally related to other cardioactive drugs.

In addition to verapamil hydrochloride, the verapamil hydrochloride extended-release capsules (PM) contain the following inactive ingredients: ammonium hydroxide, colloidal anhydrous silica, dibutyl sebacate, diethyl phthalate, ethylcellulose, hypromellose, maltodextrin, methacrylic acid copolymer, oleic acid, polyethylene glycol, povidone, silicon dioxide, sugar spheres, sodium lauryl sulfate and talc.

Each of the empty gelatin capsules for the 100 mg, 200 mg and 300 mg capsule strengths contain the following: D&C Red No. 28 aluminum lake, D&C Red No. 33 aluminum lake, D&C Yellow No. 10 aluminum lake, FD&C Red No. 40 aluminum lake, gelatin, and titanium dioxide. In addition, the 200 mg empty gelatin capsule contains FD&C Yellow No. 6 aluminum lake.

The imprinting ink contains the following: black iron oxide, D&C Yellow No. 10 aluminum lake, FD&C Blue No. 1 aluminum lake, FD&C Blue No. 2 aluminum lake, FD&C Red No. 40 aluminum lake, propylene glycol, and shellac glaze.